What question did this study set out to answer?

This research investigates the proarrhythmic effects of DL- and D-sotalol on arrhythmias in isolated ventricular myocardium exposed to normoxia and ischemia.

January 1, 1998Journal of Cardiovascular Pharmacology

Proarrhythmic Effects of DL- and D-Sotalol on the "Border Zone" Between Normal and Ischemic Regions of Isolated Ventricular Myocardium and Antiarrhythmic Effects on Reperfusion

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Population

Isolated guinea-pig ventricular strips partly exposed to normoxia and partly to modified Tyrode's solution…

Comparison

DL- and D-sotalol (5 and 10 microM) vs Controls (reference experiments)

Design

Preclinical

Follow-up

15 or 30 min ischemia followed by 30 min reperfusion

Authors

SPSandra PicardSociété Française de Médecine Vasculaire RRRené RouetNormandie Université FMFrancesco MontiGriffith University

Discussion

Member takes

Implication

Supports caution with sotalol in ischemia; leaves open translation to human proarrhythmic risk and SWORD mortality.

Key Points

This research investigates the proarrhythmic effects of DL- and D-sotalol on arrhythmias in isolated ventricular myocardium exposed to normoxia and ischemia.
Utilized isolated guinea-pig ventricular strips exposed to normoxic and ischemic conditions.
Administered DL- and D-sotalol at 5 and 10 microM concentrations during the experiment.
Applied the Weibull's model to analyze data on arrhythmia incidence.
DL- and D-sotalol significantly increased arrhythmia incidence during ischemia (p = 0.0367).
At 10 microM, DL-sotalol prevented spontaneous arrhythmias during reperfusion (p = 0.0001).
AP duration in the normal zone increased by 90% at p < 0.05 with sotalol treatment.

Structured PICO

Population

Isolated guinea-pig ventricular strips partly exposed to normoxia and partly to modified Tyrode's solution (ischemia) in an in vitro model of 'border zone' arrhythmias

Intervention

DL- and D-sotalol (5 and 10 microM)

Comparator

Controls (reference experiments)

Outcome

Incidence of spontaneous arrhythmias during ischemia and reperfusionsurrogate

In an in vitro guinea-pig model, DL- and D-sotalol exhibited proarrhythmic effects during ischemia by increasing spontaneous arrhythmias, providing a potential mechanistic explanation for the increased mortality observed in the SWORD trial.

Cite This Study

Picard et al. (1998) studied this question.

synapsesocial.com/papers/6a7152a3ce524a4339c4e22b https://doi.org/10.1097/00005344-199801000-00018

Topics

Women and heart disease

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Proarrhythmic Effects of DL- and D-Sotalol on the "Border Zone" Between Normal and Ischemic Regions of Isolated Ventricular Myocardium and Antiarrhythmic Effects on Reperfusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Proarrhythmic Effects of DL- and D-Sotalol on the "Border Zone" Between Normal and Ischemic Regions of Isolated Ventricular Myocardium and Antiarrhythmic Effects on Reperfusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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