Why the study?
Does nebivolol 5 mg once daily reduce systemic oxidative stress in healthy volunteers?
Population
12 young healthy volunteers
Comparison
Nebivolol 5 mg once daily for 7 days vs Placebo for 7 days
Design
RCT, double-blind
Follow-up
7 days per treatment period
Authors
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Nebivolol exhibits antioxidative effects in healthy volunteers; extends evidence for pleiotropic actions of third-generation beta-blockers beyond BP reduction.
Does nebivolol 5 mg once daily reduce systemic oxidative stress in healthy volunteers?
Nebivolol at antihypertensive doses significantly reduces systemic oxidative stress in healthy volunteers, suggesting additional antioxidative properties beyond beta-blockade.
Troost et al. (2000) studied this question.
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