Population
Single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts
Design
Preclinical
Authors
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Suggests dronedarone may modulate sinus node via I(K(ACh)) blockade in animals; leaves open clinical translation and human validation.
Dronedarone potently blocks Acetylcholine-activated K+ channels in rabbit sinoatrial node cells, likely by disrupting G-protein-mediated activation or direct channel interaction.
Altomare et al. (2000) studied this question.
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