Population
Rabbit cardiac Purkinje fibres
Comparison
Acetylcholine application, with voltage clamp… vs Background inward rectifier (iK1) current
Design
Preclinical
Authors
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Distinguishes ACh-activated K+ current in Purkinje fibers; hypothesis-generating for vagal arrhythmogenesis and requires human validation before any clinical consideration.
Acetylcholine induces a distinct potassium current in rabbit cardiac Purkinje fibres that differs from the background inward rectifier current.
Carmeliet et al. (1986) studied this question.
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