What question did this study set out to answer?

To compare the effects of acetylcholine on calcium (Ca2+) and potassium (K+) currents in frog atrial and ventricular myocytes.

August 1, 1987The Journal of PhysiologyOpen Access

Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.

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Authors

HHH. Criss HartzellElectrophysiology MSMark A. SimmonsUniversity of Maryland Eastern Shore

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Implication

Randomized trial compares effects of acetylcholine on calcium and potassium currents in frog atrial and ventricular myocytes, suggesting implications for heart function.

Key Points

To compare the effects of acetylcholine on calcium (Ca2+) and potassium (K+) currents in frog atrial and ventricular myocytes.
Measured Ca2+ and K+ currents using whole-cell patch-clamp technique in frog heart myocytes.
Blocked K+ currents with Cs+ and Ba2+, and fast Na+ current with tetrodotoxin (TTX).
Assessed changes in inward and outward currents during depolarization with and without ACh.
ICa was larger in ventricular myocytes (3.4 +/- 2.5 microA/cm2) compared to atrial myocytes (1.6 +/- 2.5 microA/cm2).
ACh had no effect on basal ICa when K+ currents were blocked, but reduced net inward current and increased outward current when K+ channels were open.
The steady-state ACh-activated K+ current was larger in atrial cells (3.67 +/- 1.7 microA/cm2) compared to ventricular cells (1.0 +/- 0.7 microA/cm2).

Cite This Study

Hartzell et al. (1987) studied this question.

synapsesocial.com/papers/6a6c9a11febe604dd7078ddd https://doi.org/10.1113/jphysiol.1987.sp016663

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Implication

Randomized trial compares effects of acetylcholine on calcium and potassium currents in frog atrial and ventricular myocytes, suggesting implications for heart function.

Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.

Discussion

Member takes

Implication

Key Points

Cite This Study

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