What question did this study set out to answer?

This study aims to investigate how omeprazole influences the metabolism of moclobemide based on the genetic variations of CYP2C19.

April 1, 2001Clinical Pharmacology & Therapeutics

Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19

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This study aims to investigate how omeprazole influences the metabolism of moclobemide based on the genetic variations of CYP2C19.
Conducted a randomized, single-blind, placebo-controlled, two-period crossover trial with 16 healthy volunteers.
Participants were categorized into extensive metabolizers and poor metabolizers of CYP2C19 based on genotyping.
Pharmacokinetic studies were conducted after coadministration of moclobemide with either placebo or omeprazole.
In extensive metabolizers, omeprazole significantly inhibited moclobemide metabolism after a single dose.
After one week of omeprazole, moclobemide pharmacokinetics in extensive metabolizers resembled those of poor metabolizers.
Poor metabolizers showed no significant changes in pharmacokinetic parameters with omeprazole administration.

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Implication

Randomized trial examines how omeprazole affects moclobemide levels in subjects with different CYP2C19 genotypes, suggesting significant interaction for extensive metabolizers.

Cite This Study

K. Yu (2001) studied this question.

synapsesocial.com/papers/6a71545fe5469ee92be1e3e6 https://doi.org/10.1067/mcp.2001.114231

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Implication

Randomized trial examines how omeprazole affects moclobemide levels in subjects with different CYP2C19 genotypes, suggesting significant interaction for extensive metabolizers.

Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19

Key Points

Discussion

Implication

Cite This Study

Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19

Key Points

Discussion

Implication

Cite This Study

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