What question did this study set out to answer?

To determine whether thyrotropin-releasing hormone is the exclusive physiologic mediator stimulating prolactin secretion during infant suckling.

May 23, 1974New England Journal of Medicine

Thyrotropin-Releasing Hormone Is Not the Sole Physiologic Mediator of Prolactin Release during Suckling

View Full Paper

Ask AI

Bookmark

Authors

KGKaare M. GautvikLovisenberg Diakonale Sykehus ATA H TashjianBoston University IKI. A. KouridesSt. Luke's-Roosevelt Hospital Center

Discussion

Member takes

Overview

Physiological study reveals selective prolactin release without thyrotropin elevation in postpartum women, suggesting thyrotropin-releasing hormone is not the sole mediator.

Key Points

To determine whether thyrotropin-releasing hormone is the exclusive physiologic mediator stimulating prolactin secretion during infant suckling.
Measured circulating levels of prolactin, thyrotropin, triiodothyronine, and thyroxine during suckling in N=7 postpartum women.
Administered graded intravenous doses (1, 2, 6, and 300 μg) of exogenous thyrotropin-releasing hormone to evaluate pituitary lactotroph and thyrotroph responsiveness.
Suckling elicited a selective elevation in serum prolactin while circulating thyrotropin, triiodothyronine, and thyroxine remained unchanged.
Exogenous thyrotropin-releasing hormone at 6 and 300 μg increased both prolactin and thyrotropin concentrations, whereas 1 and 2 μg doses produced no detectable release of either hormone.

Cite This Study

Gautvik et al. (1974) studied this question.

synapsesocial.com/papers/6a71550da528af2d65c406f2 https://doi.org/10.1056/nejm197405232902103

View Full Paper

Ask AI

Bookmark

May 23, 1974New England Journal of Medicine

Thyrotropin-Releasing Hormone Is Not the Sole Physiologic Mediator of Prolactin Release during Suckling

View Full Paper

Ask AI

Bookmark

Authors

KGKaare M. GautvikLovisenberg Diakonale Sykehus ATA H TashjianBoston University IKI. A. KouridesSt. Luke's-Roosevelt Hospital Center

Discussion

Member takes

Overview

Physiological study reveals selective prolactin release without thyrotropin elevation in postpartum women, suggesting thyrotropin-releasing hormone is not the sole mediator.

Key Points

To determine whether thyrotropin-releasing hormone is the exclusive physiologic mediator stimulating prolactin secretion during infant suckling.
Measured circulating levels of prolactin, thyrotropin, triiodothyronine, and thyroxine during suckling in N=7 postpartum women.
Administered graded intravenous doses (1, 2, 6, and 300 μg) of exogenous thyrotropin-releasing hormone to evaluate pituitary lactotroph and thyrotroph responsiveness.
Suckling elicited a selective elevation in serum prolactin while circulating thyrotropin, triiodothyronine, and thyroxine remained unchanged.
Exogenous thyrotropin-releasing hormone at 6 and 300 μg increased both prolactin and thyrotropin concentrations, whereas 1 and 2 μg doses produced no detectable release of either hormone.

Cite This Study

Gautvik et al. (1974) studied this question.

synapsesocial.com/papers/6a71550da528af2d65c406f2 https://doi.org/10.1056/nejm197405232902103

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark