Male patients with Brugada syndrome are more likely to manifest a spontaneous type 1 ECG pattern, suggesting a dynamic role of hormones on the phenotype.
Should not yet change Brugada management; hypothesis-generating for hormone-targeted trials.
Brugada syndrome (BrS) is an inherited arrhythmic disorder characterized by electrocardiogram (ECG) features of persistent right precordial ST segment elevation (≥2 mm) in ≥1 lead (type I BrS ECG pattern) and a predilection for syncope or sudden death owing to ventricular fibrillation. The ECG features can occur spontaneously or after pharmacologic challenge, but the risk of cardiac events is higher if the type 1 pattern occurs spontaneously.1,2 Male patients with BrS are more likely to manifest a spontaneous type 1 ECG pattern (8:1) and consequently may have a greater risk of arrhythmia and sudden death.
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Vrtikapa et al. (2024) studied this question.
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