Why the study?
What are the physiologic effects of experimentally induced acute pericardial effusion in awake goats?
What are the physiologic effects of experimentally induced acute pericardial effusion in awake goats?
Acute pericardial effusion in an awake goat model causes significant hemodynamic compromise characterized by decreased cardiac index and elevated right atrial pressure.
Acute effusion impairs hemodynamics in awake goats; leaves open translation to human tamponade.
Awake, unmedicated goats were used to study the physiologic effects of experimentally induced acute pericardial effusion. With an increase in pericardial volumes, there was a significant (P < 0.01) linear decrease in the cardiac index. This decrease was apparently due to the decrease in stroke index (P < 0.01) rather than to a decrease in heart rate. Peripheral vascular resistance in both the systemic and pulmonary arteries increased. The aortic pressure initially fell, but later rose with an increase in pericardial volumes. Pulmonary arterial pressures decreased with an increase in pericardial volumes. Pressure in the right atrium were significantly elevated (P < 0.01) with an increase in pericardial volumes.
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Wingfield et al. (1980) studied this question.
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