Understanding neuroleptic receptor binding provides a rational basis for selecting agents to minimize unwanted effects.
May guide neuroleptic selection to limit side effects; leaves open prospective outcome validation.
Table 2 summarizes the potential clinical consequences of neurotransmitter receptor blockade by neuroleptics. These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therapeutic and certain adverse effects as well as some drug-drug interactions. Data presented here should allow the physician a rational basis for selecting neuroleptics to minimize these unwanted effects in patients.
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Elliott Richelson (1988) studied this question.
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