April 1, 1981American Journal of Psychiatry
Dopamine receptors, neuroleptics, and schizophrenia
Population
Deceased schizophrenic patients (brain specimens)
Design
Review
Authors
Discussion
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Member takes
Implication
Supports DA-2 mediation of antipsychotic effects; leaves open whether radioreceptor assays improve therapeutic monitoring.
Structured PICO
P
Population
Deceased schizophrenic patients (brain specimens)
I
Intervention
Neuroleptic drugs
O
Outcome
Dopamine receptor binding and blood levels of neurolepticssurrogate
Neuroleptic drugs mediate their antipsychotic effects via DA-2 receptors, and a radioreceptor assay can be used to monitor their blood levels.
Cite This Study
Solomon H. Snyder (1981) studied this question.