Why the study?
Does the combination of dipyridamole and aspirin inhibit shear-induced platelet aggregation in whole blood and platelet-rich plasma?
Population
In vitro whole blood and platelet-rich plasma (PRP) samples
Comparison
Dipyridamole and acetylsalicylic acid alone or… vs Individual agents vs combination, and untreated…
Design
Preclinical
Authors
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Points to RBC involvement in dipyridamole-aspirin synergy on shear-induced aggregation; leaves open human translation.
Does the combination of dipyridamole and aspirin inhibit shear-induced platelet aggregation in whole blood and platelet-rich plasma?
The combination of dipyridamole and aspirin synergistically inhibits shear-induced platelet aggregation in whole blood, likely through an effect involving red blood cells.
Nakamura et al. (2002) studied this question.
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