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February 1, 1989European Heart Journal

Prevention of aortocoronary vein-graft attrition with low-dose aspirin and triflusal, both associated with dipyridamole: a randomized, double-blind, placebo-controlled trial

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Why the study?

Does low-dose aspirin plus dipyridamole or triflusal plus dipyridamole prevent aortocoronary vein-graft occlusion in patients undergoing aortocoronary vein-graft surgery compared to placebo?

Population

209 patients undergoing aortocoronary vein-graft surgery

Comparison

Low-dose aspirin plus dipyridamole OR triflusal… vs Placebo

Design

RCT, randomized, double-blind

Follow-up

6 months

Authors

PGPere GuiterasGeneralitat de CatalunyaJAJordi AltimirasLinköping UniversityAAAnna Arı́sInstitute of Agrifood Research and Technology

Discussion

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Implication

Triflusal-dipyridamole may reduce distal anastomosis occlusion after CABG versus aspirin; extends RCT evidence for optimized antiplatelet regimens in surgical revascularization.

Structured PICO

Does low-dose aspirin plus dipyridamole or triflusal plus dipyridamole prevent aortocoronary vein-graft occlusion in patients undergoing aortocoronary vein-graft surgery compared to placebo?

P
Population
209 patients undergoing aortocoronary vein-graft surgery
I
Intervention
Low-dose aspirin plus dipyridamole OR triflusal plus dipyridamole
C
Comparator
Placebo
O
Outcome
Aortocoronary vein-graft occlusion assessed by angiographic control at 9 days and 6 monthssurrogate

Triflusal plus dipyridamole appears superior to low-dose aspirin plus dipyridamole and placebo in preventing aortocoronary vein-graft occlusion at 6 months.

Cite This Study

Guiteras et al. (1989) studied this question.

synapsesocial.com/papers/6a7155cf84cc45bb7bdfedaehttps://doi.org/10.1093/oxfordjournals.eurheartj.a059456
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of early aortocoronary bypass occlusion by low-dose aspirin and dipyridamole. Grupo Español para el Seguimiento del Injerto Coronario (GESIC)1990 · 96 citations
  2. 2Randomised placebo controlled trial of aspirin and dipyridamole in the prevention of coronary vein graft occlusion.1985 · 63 citations
  3. 3A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations1982 · 540 citations
  4. 4The role of dipyridamole in addition to low dose aspirin in the prevention of occlusion of coronary artery bypass grafts1992 · 16 citations
  5. 5Random control trial of a short course of aspirin and dipyridamole (Persantin) for femorodistal grafts1987 · 89 citations