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January 1, 1986European Heart Journal

Evaluation of antiplatelet agents in the prevention of aorto-coronary bypass occlusion*

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Why the study?

Do antiplatelet agents or oral anticoagulants prevent aorto-coronary bypass occlusion in patients undergoing venous bypass grafts?

Population

Patients undergoing aorto-coronary artery venous bypass grafts

Design

Review

Follow-up

6 to 12 months

Authors

MVM VerstraeteStoke Mandeville HospitalBBB G BrownWinnMedJCJ. H. ChesebroJacksonville College

Discussion

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Implication

May support dipyridamole-aspirin over delayed anticoagulants for graft patency; leaves open confirmation in randomized trials.

Structured PICO

Do antiplatelet agents or oral anticoagulants prevent aorto-coronary bypass occlusion in patients undergoing venous bypass grafts?

P
Population
Patients undergoing aorto-coronary artery venous bypass grafts
I
Intervention
Oral anticoagulants or platelet inhibitor drugs (specifically dipyridamole started before surgery, followed by dipyridamole and aspirin soon after surgery)
O
Outcome
Aorto-coronary bypass graft occlusionsurrogate

Dipyridamole combined with aspirin appears to be the most effective regimen for preventing aorto-coronary venous bypass graft occlusion, while oral anticoagulants show no significant benefit.

Limitations

  • Lack of sufficient randomized double-blind clinical trials to confirm findings and resolve relative efficacy and safety

Cite This Study

Verstraete et al. (1986) studied this question.

synapsesocial.com/papers/6a7155cf84cc45bb7bdfedafhttps://doi.org/10.1093/oxfordjournals.eurheartj.a061955

Topics

Anticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of platelets and platelet inhibitors in aortocoronary artery vein-graft disease.1986 · 132 citations
  2. 2Platelet-Inhibitor Drugs before and after Coronary Artery Bypass Surgery and Coronary Angioplasty: The Basis of Their Use, Data from Animal Studies, Clinical Trial Data, and Current Recommendations2008 · 32 citations
  3. 3A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations1982 · 540 citations
  4. 4Optimal antithrombotic therapy following aortocoronary bypass: A meta-analysis1993 · 119 citations
  5. 5Efficacy and safety of anticoagulant therapy started pre-operatively in preventing coronary vein graft occlusion1992 · 23 citations