Antibody Production by Nonimmune Spleen Cells Incubated with RNA from Immunized Mice

RNA isolated from the spleens of B(6)AF(1) mice immunized to sheep red blood cells was incubated with the spleen cells of nonimmunized mice. The number of antibody-forming cells detected by the Jerne plaque technique was significantly higher among the cells incubated with the RNA from immune animals than among cells incubated without RNA, or with RNA from nonimmune animals.