What question did this study set out to answer?

To evaluate whether repeated autotransplantation of cryopreserved ovarian cortical tissue into heavily irradiated pelvic tissue can restore fertility and lead to a viable pregnancy.

December 24, 2014Acta Obstetricia Et Gynecologica ScandinavicaOpen Access

Full‐term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy

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Authors

KRKenny A. Rodriguez‐WallbergKarolinska University Hospital PKPer‐Olof KarlströmKarolinska University Hospital MRMasoumeh RezapourKarolinska University Hospital

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Implication

Case report demonstrates a full-term birth following repeated ovarian tissue transplants in a patient after sterilizing radiotherapy, highlighting feasibility of fertility preservation.

Key Points

To evaluate whether repeated autotransplantation of cryopreserved ovarian cortical tissue into heavily irradiated pelvic tissue can restore fertility and lead to a viable pregnancy.
A patient treated 14 years prior with 54 Gy sterilizing pelvic radiotherapy and 40 weeks of intensive chemotherapy for Ewing's sarcoma underwent sequential autotransplantations of cryopreserved ovarian tissue.
Uterine enlargement and transplant activity were monitored via sequential ultrasonography, followed by in vitro fertilization and single embryo transfer.
Transplant enlargement, uterine growth, and development of fertilizable oocytes were achieved after an incremental increase in the volume of transplanted ovarian tissue.
Single embryo transfer resulted in an uncomplicated pregnancy and the full-term delivery of a healthy infant via cesarean section, with no maternal or neonatal complications.

Cite This Study

Rodriguez‐Wallberg et al. (2014) studied this question.

synapsesocial.com/papers/6a7157145671bbf00bc2df8a https://doi.org/10.1111/aogs.12568

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Implication

Case report demonstrates a full-term birth following repeated ovarian tissue transplants in a patient after sterilizing radiotherapy, highlighting feasibility of fertility preservation.

Full‐term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy

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Implication

Key Points

Cite This Study

Full‐term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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