What question did this study set out to answer?

To develop and evaluate a biocompatible, referenced luminescent sensor for high-resolution two-dimensional imaging of in vivo pH distribution in biological tissues.

January 24, 2011Proceedings of the National Academy of SciencesOpen Access

2D luminescence imaging of pH in vivo

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To develop and evaluate a biocompatible, referenced luminescent sensor for high-resolution two-dimensional imaging of in vivo pH distribution in biological tissues.
Synthesized a ratiometric sensor utilizing time-domain luminescence imaging with fluorescein isothiocyanate (FITC) and ruthenium(II)tris-(4,7-diphenyl-1,10-phenanthroline).
Incorporated indicator dyes into aminocellulose and polyacrylonitrile microparticles and immobilized them within a polyurethane hydrogel on transparent foil.
Assessed sensor accuracy, stability, and biocompatibility through in vitro models and in vivo monitoring of acute and chronic cutaneous wounds in human subjects.
Demonstrated reliable, high-resolution 2D mapping of pH values in human subjects during both physiological and chronic cutaneous wound healing.
Maintained sensor precision, valid calibration, and biocompatibility in vivo under varying physiological conditions without systemic disruption.

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Implication

Experimental study demonstrates biocompatible two-dimensional luminescent pH imaging in human cutaneous wounds, suggesting valuable diagnostic potential for chronic wound care and tumor biology.

Cite This Study

Schreml et al. (2011) studied this question.

synapsesocial.com/papers/6a7158f0a2d7cf2e39c2c98d https://doi.org/10.1073/pnas.1006945108

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Implication

Experimental study demonstrates biocompatible two-dimensional luminescent pH imaging in human cutaneous wounds, suggesting valuable diagnostic potential for chronic wound care and tumor biology.

2D luminescence imaging of pH in vivo

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Discussion

Implication

Cite This Study

2D luminescence imaging of pH in vivo

Key Points

Discussion

Implication

Cite This Study

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