Key result
A negative Master two-step test reliably excludes significant myocardial ischemia, led by post-exercise ECG.
Observational (n=800)
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Silent coronary artery disease presents a problem of great magnitude, affecting an estimated 2 million persons or more yearly. The Master test is of great value in the detection of such asymptomatic, ischemic heart disease. On the basis of long-term studies in 800 patients, it was substantiated that a negative twostep test virtually excludes significant myocardial ischemia. The response may be considered positive when ischemic depression of the RS-T segment occurs, or when a j-type RS-T depression is characterized by both a prolonged systole (QT ratio abnormal) and a duration prolonged in relation to this systole (QX/QT abnormal). The experienced physician can usually interpret these electrocardiographic changes by visual inspection. Monitoring of the two-step test has research potential, but at present is not as sensitive as the post-exercise electrocardiogram.
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Mastér et al. (1964) conducted an observational in Silent coronary artery disease / asymptomatic ischemic heart disease (n=800). Master two-step exercise test (monitored and post-exercise) was evaluated on Detection of significant myocardial ischemia. A negative Master two-step test in 800 patients virtually excluded significant myocardial ischemia, with post-exercise ECG proving more sensitive than monitored testing.
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