Why the study?
Coxsackievirus A4 is a prevalent pathogen associated with hand, foot and mouth disease and conditions including myocarditis, but limited genome sequences are currently available.
Population
21 CVA4 strains isolated from HFMD patients in Shandong, China and 175 strains for VP1 analysis
Design
Phylogenetic and genomic characterization study
Authors
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Enhances CVA4 genomic surveillance for HFMD; leaves open myocarditis associations pending clinical correlation.
Phylogenetic analysis of CVA4 isolates from China reveals significant intra-genotypic genetic diversity and ongoing evolution, highlighting VP1 as a stable target for diagnostics and vaccines.
Wang et al. (2019) studied this question.
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