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March 1, 1992Journal of General Virology

The nucleotide sequences of wild-type coxsackievirus A9 strains imply that an RGD motif in VP1 is functionally significant

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Population

5 strains of wild-type coxsackievirus A9 isolated over a 25 year period, compared to the prototype strain…

Design

Preclinical

Authors

KCKeng-Ming ChangPingtung HospitalCDCraig H. DayCorixa CorporationJWJohn WalkerTexas Parks and Wildlife Department

Discussion

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Implication

RGD conservation in diverse CVA9 strains suggests functional importance; leaves open antiviral targeting in human enteroviral disease.

Structured PICO

P
Population
5 strains of wild-type coxsackievirus A9 (CAV-9) isolated over a 25 year period, compared to the prototype strain Griggs
I
Intervention
Nucleotide sequencing of the C-terminal extension to the capsid protein VP1
O
Outcome
Nucleotide sequence identity and conservation of the RGD motif

The conservation of the RGD motif within the variable VP1 extension of coxsackievirus A9 strains implies it is functionally significant.

Cite This Study

Chang et al. (1992) studied this question.

synapsesocial.com/papers/6a715b3d5d37378ac1de83behttps://doi.org/10.1099/0022-1317-73-3-621
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus1982 · 87 citations
  2. 2RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases1991 · 153 citations
  3. 3The Nucleotide Sequence of Coxsackievirus A9; Implications for Receptor Binding and Enterovirus Classification1989 · 168 citations
  4. 4The complete nucleotide sequence of the RNA coding for the primary translation product of foot and mouth disease virus1984 · 139 citations
  5. 5Cell surface receptors for picornaviruses1986 · 42 citations