Immunocytochemical Reactions of Serum from Ulcerative Colitis Patients.

Increased gamma globulin was demonstrated in the intestinal tract of patients with active regional ileitis and ulcerative colitis. The indirect fluorescent antibody technic revealed a gamma globulin in the serum of 3 of 25 patients with ulcerative colitis which was bound to epithelial glands of colonic mucosa and of hepatic bile ductules. Sera of normals and hospital controls did not bind to colonic mucosa.