What question did this study set out to answer?

To investigate the biological effects of soy isoflavones and curcumin on prostate-specific antigen (PSA) production in vitro and evaluate their efficacy in lowering serum PSA levels in men without prostate cancer.

March 26, 2010The Prostate

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate‐specific antigen

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To investigate the biological effects of soy isoflavones and curcumin on prostate-specific antigen (PSA) production in vitro and evaluate their efficacy in lowering serum PSA levels in men without prostate cancer.
Measured androgen receptor and PSA expression in LNCaP prostate cancer cells following treatment with isoflavones, curcumin, or both.
Randomized 85 men with prior negative prostate biopsies to receive either a daily supplement containing isoflavones and curcumin or a placebo for 6 months in a double-blind trial.
Stratified clinical participants by a baseline PSA threshold of 10 μg/ml to evaluate changes in serum PSA before and after 6 months of treatment.
Combined treatment with isoflavones and curcumin markedly decreased PSA production and suppressed androgen receptor expression in LNCaP cells.
Supplementation significantly reduced serum PSA levels in clinical trial participants who had a baseline PSA ≥ 10 μg/ml (P = 0.01).

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Implication

Randomized double-blind trial demonstrates reduced prostate-specific antigen with soy isoflavones and curcumin in men with high baseline levels, suggesting potential preventive benefits.

Cite This Study

Ide et al. (2010) studied this question.

synapsesocial.com/papers/6a715d08e36a167817e331a5 https://doi.org/10.1002/pros.21147

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Implication

Randomized double-blind trial demonstrates reduced prostate-specific antigen with soy isoflavones and curcumin in men with high baseline levels, suggesting potential preventive benefits.

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate‐specific antigen

Key Points

Discussion

Implication

Cite This Study

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate‐specific antigen

Key Points

Discussion

Implication

Cite This Study

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