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RNA synthesis by the Azotobacter vinelandii RNA polymerase is initiated with the incorporation of a ribonucleoside triphosphate to form the 5' terminus of the chain. The RNA chains synthesized in vitro are preferentially initiated by purine ribonucleoside triphosphates. The ratio of guanosine triphosphate to ATP termini is determined by the DNA used to direct the synthesis of RNA. When denatured DNA is used as the template, this ratio is shifted in favor of GTP termini.
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Krakow et al. (1967) studied this question.
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