November 5, 2013Journal of the American Heart AssociationOpen Access

Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux

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Why the study?

Does cardiac-specific HK2 overexpression attenuate cardiac hypertrophy in preclinical models?

Population

Mice and neonatal rat ventricular myocytes (NRVMs)

Design

Preclinical

Authors

KMKyle S. McCommisSaint Louis University DDDiana DouglasAmerican Type Culture Collection MKMaike KrenzUniversity of Missouri

Discussion

Member takes

Implication

Preclinical HK2 data extend metabolic insights into hypertrophy; leaves open any therapeutic role in human heart failure.

Structured PICO

Does cardiac-specific HK2 overexpression attenuate cardiac hypertrophy in preclinical models?

Population

Mice and neonatal rat ventricular myocytes (NRVMs)

Intervention

Cardiac-specific hexokinase-2 (HK2) overexpression (in mice) and HK2 adenovirus infection (in NRVMs)

Outcome

Cardiac hypertrophy and reactive oxygen species (ROS) levelssurrogate

Cardiac-specific HK2 overexpression attenuates cardiac hypertrophy by decreasing reactive oxygen species accumulation via increased pentose phosphate pathway flux.

Cite This Study

McCommis et al. (2013) studied this question.

synapsesocial.com/papers/6a715e14febe604dd70a09d1 https://doi.org/10.1161/jaha.113.000355

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Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider