Why the study?
Sex-related disparities exist in non-rheumatic mitral regurgitation mechanisms, diagnostics, treatment access, and outcomes, yet current European and US guidelines do not consider sex in decision-making.
This review highlights significant sex-related disparities in the epidemiology, diagnosis, and treatment of non-rheumatic mitral regurgitation, suggesting a need for sex-specific considerations in clinical decision-making.
Answers are grounded in this paper and cite their sources.
Sex differences in mitral regurgitation may warrant consideration in management; leaves open prospective validation before sex-specific guidelines.
Sex-related disparities have been recognized in incidence, pathological findings, pathophysiological mechanisms, and diagnostic pathways of non-rheumatic mitral regurgitation. Furthermore, access to treatments and outcomes for surgical and interventional therapies among women and men appears to be different. Despite this, current European and US guidelines have identified common diagnostic and therapeutic pathways that do not consider patient sex in decision-making. The aim of this review is to summarize the current evidence on sex-related differences in non-rheumatic mitral regurgitation, particularly regarding incidence, imaging modalities, surgical-derived evidence, and outcomes of transcatheter edge-to-edge repair, with the goal of informing clinicians about sex-specific challenges to consider when making treatment decisions for patients with mitral regurgitation.
No takes yet. Share an insight, caveat, or question.
Tersalvi et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: