Increased Oxidative Stress in Experimental Renovascular Hypertension
Population
Pigs (n=14)
Comparison
Induction of unilateral renal artery stenosis vs Sham operation (n=7)
Design
Preclinical
Follow-up
10 weeks
Authors
Discussion
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Member takes
Implication
May implicate sustained oxidative stress in renovascular hypertension; leaves open whether targeting it alters outcomes in patients.
Structured PICO
P
Population
Pigs (n=14)
I
Intervention
Induction of unilateral renal artery stenosis (n=7)
C
Comparator
Sham operation (n=7)
O
Outcome
Levels of PGF(2alpha)-isoprostanes, plasma renin activity, mean arterial pressure, and renal blood flow at 5 and 10 weekssurrogate
In experimental renovascular hypertension, systemic oxidative stress increases early and remains elevated even after plasma renin activity normalizes, suggesting a role in sustaining elevated arterial pressure.
Cite This Study
Lerman et al. (2001) studied this question.