Key result
Reduced renal function is linked to ~39% higher risk of arterial stiffness in women.
Observational (n=11,767)
No
Odds Ratio: 1.39 (95% CI 1.03–1.86)
p-value: p=0.027
Supports sex-specific vascular risk assessment in practice; leaves open prospective validation of tailored interventions.
Arterial stiffness is a well-established marker of vascular aging and an independent predictor of cardiovascular morbidity and mortality [1][2][3].It reflects both structural and functional alterations in the arterial wall, including elastin degradation, collagen deposition, endothelial dysfunction, and smooth muscle remodeling [4,5].These changes are influenced by a variety of traditional cardiovascular risk factors, such as aging, hypertension, diabetes, dyslipidemia, obesity, oxidative stress, and chronic inflammation [4].Among various methods available to assess arterial stiffness, pulse wave velocity (PWV) is the most widely used and validated noninvasive technique [4,5].PWV measures
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Kim et al. (2026) conducted an observational in Cardiovascular risk factors (n=11,767). Reduced renal function (eGFR <60 mL/min/1.73 m2) in women vs. Normal renal function (eGFR ≥60 mL/min/1.73 m2) in women was evaluated on Increased arterial stiffness (baPWV ≥1,800 cm/s) (OR 1.39, 95% CI 1.03-1.86, p=0.027). Reduced renal function was independently associated with increased arterial stiffness in women (OR 1.39), whereas lower BMI was an independent predictor in men, highlighting sex-specific determinants of vascular aging.
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