January 1, 1996Annals of Internal Medicine
Glycemic Control and the Risk for Coronary Heart Disease in Patients with Non-Insulin-dependent Diabetes Mellitus: The Finnish Studies
Why the study?
Is glycemic control associated with the risk of coronary heart disease and cardiovascular mortality in patients with non-insulin-dependent diabetes mellitus?
Population
362 patients with non-insulin-dependent diabetes mellitus from eastern Finland
Design
Review
Follow-up
Up to 10 years (Study 1) and up to 3.5 years (Study 2)
Authors
Discussion
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Member takes
Implication
Supports glycemic monitoring for risk stratification in type 2 diabetes; leaves open whether intervention trials confirm mortality benefit.
Structured PICO
Is glycemic control associated with the risk of coronary heart disease and cardiovascular mortality in patients with non-insulin-dependent diabetes mellitus?
P
Population
362 patients with non-insulin-dependent diabetes mellitus (NIDDM) from eastern Finland (Study 1: n=133 newly diagnosed, aged 45-64 years; Study 2: n=229 newly or previously diagnosed, aged 65-74 years)
I
Intervention
Glycemic control (measured by fasting blood glucose and glycated hemoglobin A1/A1c levels)
O
Outcome
Cardiovascular mortality (Study 1) and coronary heart disease mortality or all coronary heart disease events (mortality or nonfatal myocardial infarction) (Study 2)hard clinical
This review of two Finnish cohorts demonstrates a significant, independent, and linear association between poor glycemic control and increased risk of cardiovascular and coronary heart disease mortality in patients with type 2 diabetes.
Cite This Study
Markku Laakso (1996) studied this question.