Why the study?
Many pharmacologic agents have been investigated to prevent delirium, but a comprehensive comparison of their effects to prevent postoperative delirium was needed.
Do pharmacological interventions reduce the postoperative incidence of delirium in adult patients undergoing surgery?
Comparison
Pharmacological interventions vs another drug or placebo
Design
Bayesian network meta-analysis of randomized trials using a random effects model
Authors
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Dexmedetomidine or atypical antipsychotics may be preferred to prevent postoperative delirium; extends comparative RCT evidence but heterogeneity leaves optimal choice open.
Do pharmacological interventions reduce the postoperative incidence of delirium in adult patients undergoing surgery?
Dexmedetomidine, haloperidol, and atypical antipsychotics are effective in reducing the incidence of postoperative delirium compared to placebo.
Park et al. (2021) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: