Key result
Lower global circumferential strain is linked to an ~5-fold higher MACE risk in ICI myocarditis.
Why the study?
Data are limited on the effect of immune checkpoint inhibitor myocarditis on global circumferential strain and global radial strain.
Do global circumferential and radial strain measurements predict major adverse cardiovascular events in patients with immune checkpoint inhibitor myocarditis?
Population
75 ICI myocarditis cases and 50 ICI-treated controls without myocarditis
Comparison
ICI myocarditis cases vs ICI-treated controls without myocarditis
Design
Retrospective study with blinded core laboratory analysis
Follow-up
Median 30 days
Authors
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Global circumferential and radial strain are significantly reduced in ICI myocarditis and provide incremental prognostic value over LVEF and troponin for predicting major adverse cardiovascular events.
Case-Control (n=125)
Single-blind (outcome assessors)
Yes
Do global circumferential and radial strain measurements predict major adverse cardiovascular events in patients with immune checkpoint inhibitor myocarditis?
Hazard Ratio: 4.9 (95% CI 1.6–15)
p-value: p=0.005
Global circumferential and radial strain are significantly reduced in ICI myocarditis and provide incremental prognostic value over LVEF and troponin for predicting major adverse cardiovascular events.
Quinaglia et al. (2022) conducted a case-control in Immune checkpoint inhibitor myocarditis (n=125). Global circumferential strain (GCS) below median (17.1%) vs. GCS above median was evaluated on Major adverse cardiovascular events (MACE) (HR 4.9, 95% CI 1.6-15.0, p=0.005). Among patients with immune checkpoint inhibitor myocarditis, a global circumferential strain below the median was associated with a nearly five-fold increased risk of major adverse cardiovascular events (HR 4.9).
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