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July 21, 2022Journal of Ultrasound in Medicine

Evaluating Tumor‐Infiltrating Lymphocytes in Breast Cancer

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Authors

YJYingying JiaGansu Provincial HospitalYZYangyang ZhuBinzhou Medical UniversityTLTing LiNanjing Medical University

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Overview

Retrospective study finds ultrasound and contrast-enhanced imaging predict tumor-infiltrating lymphocyte levels in breast cancer, highlighting potential for noninvasive treatment planning.

Key Points

  • To evaluate the association between conventional ultrasound and contrast-enhanced ultrasound (CEUS) imaging characteristics and tumor-infiltrating lymphocyte (TIL) levels in patients with invasive breast cancer.
  • Retrospective study of N=267 women with invasive breast cancer who underwent preoperative conventional ultrasound and CEUS.
  • Patients were categorized into low (≤10%) and high (>10%) TIL groups, with imaging features evaluated independently by two sonographers.
  • High TIL tumors were significantly associated with circumscribed margins, oval or round shapes, enhanced posterior echoes, homogeneous enhancement, and higher peak intensity (p < 0.05).
  • Low TIL tumors presented more frequently with irregular shapes as well as uncircumscribed, indistinct, and spiculated margins (p < 0.05).
  • A multivariable model combining shape, posterior features, peak intensity, and enhancement homogeneity predicted high TIL tumors with an AUC of 0.79, sensitivity of 0.72, and specificity of 0.78.

Cite This Study

Jia et al. (2022) studied this question.

synapsesocial.com/papers/6a7164f1439bab0cabc39072https://doi.org/10.1002/jum.16058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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