Key result
Digoxin-specific antibody fragments effectively treat life-threatening arrhythmias from digoxin toxicity in renal insufficiency.
Why the study?
Digoxin toxicity has become uncommon due to reduced usage and dosage, meaning it may be overlooked when it occurs.
Case Report (n=1)
Digoxin toxicity remains a life-threatening complication, particularly in elderly patients with renal insufficiency, and requires prompt recognition and treatment with digoxin-specific antibody fragments.
Digoxin usage has decreased in the treatment of congestive heart failure and atrial fibrillation as a result of its inferiority to beta-adrenergic inhibitors and agents that interfere with the deleterious effects of the activated renin-angiotensin-aldosterone system. As a result of reduction of usage and dosage, glycoside toxicity has become an uncommon occurrence but may be overlooked when it does occur. Older age, female sex, low lean body mass, and renal insufficiency contribute to higher serum levels and enhanced risk for toxicity. Arrhythmias suggesting digoxin toxicity led to its recognition in the case presented here.
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Yang et al. (2012) conducted a case report in Digitalis toxicity (n=1). Digoxin was evaluated. Digoxin toxicity can present with life-threatening arrhythmias, particularly in patients with renal insufficiency, and can be effectively treated with digoxin-specific antibody fragments.
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