Why the study?
Does digoxin at SDC 0.5-0.9 ng/mL reduce mortality and hospitalizations in heart failure patients?
Does digoxin at SDC 0.5-0.9 ng/mL reduce mortality and hospitalizations in heart failure patients?
Targeting a lower serum digoxin concentration (0.5-0.9 ng/mL) may reduce both mortality and hospitalizations across the spectrum of heart failure, including preserved systolic function.
May support SDC-guided digoxin in HF; leaves open randomized confirmation across phenotypes.
Digoxin at SDC 0.5-0.9 ng/mL reduces mortality and hospitalizations in all HF patients, including those with preserved systolic function. At higher SDC, digoxin reduces HF hospitalization but has no effect on mortality or all-cause hospitalizations.
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Ahmed et al. (2005) studied this question.
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