THE RELATIONSHIP of the thyroid gland to metabolism has long been recognized though little understood. The fact that utilization ofoxygen by the intact, hyperthyroid animal is increased does not necessarilymean that every tissue is using more oxygen nor that thosewhich do respond to this stimulation do so at the same rate, to thesame extent or in the same manner. Techniques by which the oxidativeprocesses can be studied in individual tissues have already contributedto our knowledge of the mechanics of this relationship. Somecontradiction exists as to the ability of thyroxine to exert its stimulativeeffect on isolated, surviving tissues, but the bulk of the evidencepoints to the negative (Haarmann, 1936; Mansfield and Horvath,1934; Büngeler, 1938; Dresel, 1938). It has been adequately shown,however, that thyroid treatment prior to the use of the animal fortissue respiration experiments results in an increased rate of oxidationin certain tissues (Dye, 1933; McEachern, 1935; Meyer et al., 1933).
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Gordon et al. (1944) studied this question.