Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling.

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 21993 · 99 citations
2. 2Enhancement or Inhibition of Insulin Signaling by Insulin Receptor Substrate 1 Is Cell Context Dependent1994 · 48 citations
3. 3Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.1994 · 128 citations
4. 4Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.1994 · 125 citations
5. 5GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.1993 · 179 citations