Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation

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Population

Cellular models

Design

Preclinical

Authors

Discussion

Animal data extend stress granule mechanisms beyond eIF2α; leaves open clinical translation in cardiovascular contexts.

Population

Cellular models

Intervention

Inhibition of eIF4A activity or inhibition of cap-dependent translation after poliovirus infection

Outcome

Stress granule (SG) formationsurrogate

Stress granule formation can occur via eIF2alpha phosphorylation-independent pathways targeting translation initiation, such as eIF4A inhibition.

Mazrouï et al. (2006) studied this question.

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