Population
Hepatitis C virus (HCV) replicon-containing cell lines
Design
Preclinical
Authors
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RBV resistance mechanisms in HCV cell lines are hypothesis-generating; prospective studies needed before any clinical consideration.
Ribavirin resistance in HCV replicon cell lines can arise from both host cell changes (defective drug import) and viral replicon mutations (NS5A region).
Pfeiffer et al. (2005) studied this question.
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