September 1, 1989Journal of Lipid ResearchOpen Access

Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein A-I gene: relationship to plasma concentration of high density lipoproteins.

View Full Paper

Ask AI

Bookmark

Why the study?

Does dietary polyunsaturated fat alter apolipoprotein A-I production compared to saturated fat in African green monkeys?

Population

African green monkeys (Cercopithecus aethiops)

Comparison

Diet containing polyunsaturated fat with high or… vs Diet containing saturated fat with high or low…

Design

Preclinical

Authors

MSMary G. Sorci‐ThomasMedical College of Wisconsin MPM M PrackBristol-Myers Squibb (Germany)NDNassrin DashtiState University of New York

Discussion

Member takes

Implication

May explain PUFA effects on HDL in primates; hypothesis-generating for human apoA-I regulation.

Structured PICO

Does dietary polyunsaturated fat alter apolipoprotein A-I production compared to saturated fat in African green monkeys?

Population

African green monkeys (Cercopithecus aethiops)

Intervention

Diet containing polyunsaturated fat (P/S = 2.2) with high (0.8 mg/kcal) or low (0.03 mg/kcal) dietary cholesterol

Comparator

Diet containing saturated fat (P/S = 0.3) with high (0.8 mg/kcal) or low (0.03 mg/kcal) dietary cholesterol

Outcome

Plasma concentrations of total cholesterol, HDL cholesterol, apoA-I, hepatic apoA-I secretion, and hepatic apoA-I mRNA concentrationssurrogate

Dietary polyunsaturated fat selectively reduces the expression of the apoA-I gene in the liver, providing a mechanism for its HDL-lowering effect.

Cite This Study

Sorci‐Thomas et al. (1989) studied this question.

synapsesocial.com/papers/6a71699a75498292b70ae428 https://doi.org/10.1016/s0022-2275(20)38254-7

View Full Paper

Ask AI

Bookmark

Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein A-I gene: relationship to plasma concentration of high density lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein A-I gene: relationship to plasma concentration of high density lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider