Key result
CSF-serum albumin ratio and MMP-9 kinetics correlate with stroke severity and 3-month functional outcomes.
Observational (n=88)
BACKGROUND/AIMS: We evaluated the cerebrospinal fluid/serum albumin ratio (AR) and kinetics of matrix metalloproteinase-9 (MMP-9) in blood as markers for blood-brain barrier (BBB) disruption after acute ischemic stroke. METHODS: The AR was determined in 88 patients with acute ischemic stroke or transient ischemic attack. MMP-9 was measured on admission, 24, 72 h and 7 days after stroke onset. RESULTS: The AR was related to stroke severity, the occurrence of stroke progression and the modified Rankin Scale score at month 3. MMP-9 levels on admission were significantly elevated compared to controls and dropped in the first 72 h after stroke, except in patients with stroke progression and larger infarcts in the subacute phase. CONCLUSIONS: We demonstrate that the extent of BBB breakdown in hyperacute stroke relates to initial stroke severity, stroke evolution and long-term outcome. The kinetics of MMP-9 confirm its pivotal role in secondary brain damage after ischemic stroke.
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Brouns et al. (2010) conducted an observational in Acute ischemic stroke or transient ischemic attack (n=88). Cerebrospinal fluid/serum albumin ratio (AR) and blood matrix metalloproteinase-9 (MMP-9) vs. Controls was evaluated on Stroke severity, stroke progression, and modified Rankin Scale score at month 3. Cerebrospinal fluid/serum albumin ratio and MMP-9 kinetics in 88 stroke/TIA patients correlated with stroke severity, progression, and month-3 modified Rankin Scale outcomes.
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