What question did this study set out to answer?

To review the development, performance, and translational challenges of materials-based intravascular oxygen carriers for treating critical hypoxic conditions.

June 27, 2018Chemistry - A European Journal

Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science

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Authors

YPYifeng PengStevens Institute of Technology JKJohn N. KheirBoston Children's Hospital BPBrian D. PolizzottiBoston Children's Hospital

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Implication

Narrative review outlines advances in intravenous oxygen delivery platforms for acute hypoxia, highlighting therapeutic potential in cardiac arrest resuscitation.

Key Points

To review the development, performance, and translational challenges of materials-based intravascular oxygen carriers for treating critical hypoxic conditions.
Evaluation of biomedical literature on synthetic intravenous oxygen platforms, focusing specifically on perfluorocarbon-based emulsions and gas microbubbles.
Comparative analysis of physicochemical properties, gas-transport kinetics, in vivo biocompatibility, and stability across preclinical models of hypoxia.
Perfluorocarbon emulsions and microbubbles demonstrate effective gas-transport mechanisms capable of rapidly perfusing hypoxic tissue beds in acute conditions such as stroke and hemorrhagic shock.
Translational utility remains restricted by major technical hurdles, including particle coalescence, poor shelf-life stability, and in vivo safety concerns.
Intravascular gas carriers show notable potential as targeted emergency resuscitative therapeutics to mitigate ischemic tissue damage during cardiac arrest.

Cite This Study

Peng et al. (2018) studied this question.

synapsesocial.com/papers/6a7169c82fdcb5703edb762a https://doi.org/10.1002/chem.201802054

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Implication

Narrative review outlines advances in intravenous oxygen delivery platforms for acute hypoxia, highlighting therapeutic potential in cardiac arrest resuscitation.

Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science

Discussion

Member takes

Implication

Key Points

Cite This Study

Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science

Discussion

Member takes

Implication

Key Points

Cite This Study

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