Why the study?
Does overexpression of cytosolic renin affect proliferation, necrosis, and apoptosis in H9c2 rat cardiomyoblasts?
Population
H9c2 rat cardiomyoblasts
Comparison
Overexpression of secretory or cytosolic renin vs Cells transfected with control vector
Design
Preclinical
Follow-up
10 days
Authors
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No immediate clinical implications; leaves open cytosolic renin's viability as a heart failure target.
Does overexpression of cytosolic renin affect proliferation, necrosis, and apoptosis in H9c2 rat cardiomyoblasts?
Cytosolic renin protects H9c2 cardiomyoblasts from necrosis but increases apoptosis, identifying it as a potential novel target in heart failure.
Wanka et al. (2008) studied this question.
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