What question did this study set out to answer?

To determine whether tumor-associated microvessel density, as a measure of angiogenesis, serves as an independent prognostic indicator of recurrence and survival in patients with invasive transitional cell carcinoma of the bladder.

November 1, 1995JNCI Journal of the National Cancer Institute

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

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Authors

BBBernard H. BochnerMemorial Sloan Kettering Cancer Center RCR. J. CoteUniversity of Miami NWNoel WeidnerUniversity of Minnesota

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Implication

Cohort study reveals higher microvessel density predicts increased recurrence and reduced survival in invasive bladder cancer, indicating its utility as an independent prognostic marker.

Key Points

To determine whether tumor-associated microvessel density, as a measure of angiogenesis, serves as an independent prognostic indicator of recurrence and survival in patients with invasive transitional cell carcinoma of the bladder.
Assessed tumor tissue from 164 patients with invasive primary transitional cell carcinoma of the bladder using immunohistochemistry with anti-CD34 monoclonal antibody (HPCA-1) to quantify microvessels per 200x high-power field (hpf) in areas of maximum neovascularization.
Stratified patients into low (≤64), intermediate (65–99), and high (≥100) microvessel density tertiles, analyzing overall and recurrence-free survival with Kaplan-Meier estimates and log-rank tests with and without stage stratification.
Microvessel density was significantly associated with recurrence-free survival (P < .0001) and overall survival (P = .0007), remaining an independent prognostic indicator when evaluated alongside histologic grade, pathologic stage, and lymph node status.
Estimated 5-year recurrence rates were 19% (95% CI = 8–29), 56% (95% CI = 43–69), and 68% (95% CI = 55–81) for patients in the low, intermediate, and high microvessel count groups, respectively.
Estimated 5-year overall survival rates were 68% (95% CI = 56–81) for the low, 44% (95% CI = 30–57) for the intermediate, and 34% (95% CI = 21–47) for the high microvessel density groups.

Cite This Study

Bochner et al. (1995) studied this question.

synapsesocial.com/papers/6a716b28febe604dd70a1691 https://doi.org/10.1093/jnci/87.21.1603

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Implication

Cohort study reveals higher microvessel density predicts increased recurrence and reduced survival in invasive bladder cancer, indicating its utility as an independent prognostic marker.

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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