May 26, 2015PLoS ONEOpen Access

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

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Why the study?

Does cardiac-specific SOCS3 deletion prevent myocardial ischemia reperfusion injury in mice?

Population

Wild-type and cardiac-specific SOCS3 knockout mice subjected to myocardial ischemia reperfusion injury

Comparison

Cardiac-specific SOCS3 deletion vs Wild-type mice

Design

Preclinical

Follow-up

24 hours after reperfusion

Authors

TNTakanobu NagataKurume University HYHideo YasukawaKurume University SKSachiko KyogokuKurume University

Discussion

Member takes

Implication

SOCS3 deletion protects against IRI in models; hypothesis-generating for STAT3-targeted therapies in reperfusion injury.

Structured PICO

Does cardiac-specific SOCS3 deletion prevent myocardial ischemia reperfusion injury in mice?

Population

Wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO) subjected to myocardial ischemia reperfusion injury (LAD ligation for 1 h followed by reperfusion)

Intervention

Cardiac-specific SOCS3 deletion

Comparator

Wild-type mice

Outcome

Infarct size 24 h after reperfusionsurrogate

Cardiac-specific SOCS3 deletion reduces myocardial ischemia-reperfusion injury by sustaining the activation of cardioprotective signaling pathways.

Cite This Study

Nagata et al. (2015) studied this question.

synapsesocial.com/papers/6a716bd3e5469ee92be1f61d https://doi.org/10.1371/journal.pone.0127942

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Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider