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July 2, 2021Frontiers in PhysiologyOpen Access

Left Atrial Wall Stress and the Long-Term Outcome of Catheter Ablation of Atrial Fibrillation: An Artificial Intelligence-Based Prediction of Atrial Wall Stress

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Why the study?

Atrial stretch may contribute to AF recurrence after AFCA, leading investigators to test whether AI could predict LA wall stress non-invasively and forecast post-AFCA rhythm outcomes.

Does high left atrial wall stress predicted by artificial intelligence predict atrial fibrillation recurrence in patients undergoing catheter ablation?

Population

2223 patients in cohort 1 and 658 patients in cohort 2 undergoing AFCA

Comparison

Highest quartile LA wall stress vs lower quartiles

Design

Cohort study (prediction model derivation and validation)

Follow-up

26.0 (12.0–52.0) months

Authors

JLJae-Hyuk LeeOKOh‐Seok KwonJSJaemin Shim

Discussion

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Member takes

Overview

AI-predicted LA wall stress was associated with post-AFCA recurrence; leaves open whether noninvasive AI risk stratification improves ablation outcomes.

Structured PICO

Does high left atrial wall stress predicted by artificial intelligence predict atrial fibrillation recurrence in patients undergoing catheter ablation?

P
Population
2,881 patients (Cohort 1: n=2,223; Cohort 2: n=658) who underwent atrial fibrillation catheter ablation (AFCA)
I
Intervention
High left atrial wall stress (highest quartile, Q4) predicted by artificial intelligence (LAW-stress [AI]) using non-invasive clinical parameters
C
Comparator
Lower quartiles of left atrial wall stress
O
Outcome
Atrial fibrillation/atrial tachycardia recurrence 3 months after the blanking period after AFCA

Higher left atrial wall stress, which can be predicted by AI using non-invasive parameters, is associated with poorer rhythm outcomes after atrial fibrillation catheter ablation.

Cite This Study

Lee et al. (2021) studied this question.

synapsesocial.com/papers/6a716d7753da1ffdb507bc6ehttps://doi.org/10.3389/fphys.2021.686507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium2019 · 56 citations
  2. 2Indexed Left Atrial Volume Is Superior to Left Atrial Diameter in Predicting Nonvalvular Atrial Fibrillation Recurrence after Successful Cardioversion: A Prospective Study2011 · 63 citations
  3. 3Association between left atrial size and atrial fibrillation recurrence after single circumferential pulmonary vein isolation: a systematic review and meta-analysis of observational studies2011 · 209 citations
  4. 4Sex differences in mapping and rhythm outcomes of a repeat atrial fibrillation ablation2021 · 29 citations
  5. 5Accuracy and clinical feasibility of 3D-myocardial thickness map measured by cardiac computed tomogram2020 · 12 citations