November 1, 1998The American Journal of Surgical Pathology

Desmoplastic Small Round Cell Tumor

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Population

39 cases of desmoplastic small round cell tumor (DSRCT)

Design

Case_series

Authors

NONelson G. OrdóǹezThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Aids exclusion of mesothelial and rhabdomyosarcomatous differentiation in small round cell tumors; leaves open multipotent progenitor origin of DSRCT.

Structured PICO

Population

39 cases of desmoplastic small round cell tumor (DSRCT)

Intervention

Immunohistochemical methods using a large battery of antibodies directed against epithelial, mesenchymal, and neural-associated proteins, and electron microscopy (in 16 cases)

Outcome

Expression of various epithelial, mesenchymal, and neural-associated proteinssurrogate

Immunohistochemical and ultrastructural analysis of DSRCTs demonstrates multiphenotypic differentiation but lacks evidence for mesothelial or skeletal muscle origin, suggesting they arise from a multipotent progenitor cell.

Cite This Study

Nelson G. Ordóǹez (1998) studied this question.

synapsesocial.com/papers/6a716de535aa2c282ce2baab https://doi.org/10.1097/00000478-199811000-00002

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Implication

Aids exclusion of mesothelial and rhabdomyosarcomatous differentiation in small round cell tumors; leaves open multipotent progenitor origin of DSRCT.

Desmoplastic Small Round Cell Tumor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Desmoplastic Small Round Cell Tumor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider