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May 1, 1991Clinical Orthopaedics and Related Research

Autologous Marrow Injection as a Substitute for Operative Grafting of Tibial Nonunions

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Authors

JCJohn F. ConnollyParker Institute for Cancer ImmunotherapyRGRoy J. GuseNebraska Medical CenterJTJ J TiedemanNebraska Medical Center

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Implication

Clinical study demonstrates high union rates using percutaneous marrow injection in tibial nonunions, indicating a viable alternative to open bone grafting.

Key Points

  • To evaluate the efficacy of percutaneous autologous bone marrow injection as a minimally invasive alternative to open bone grafting for ununited tibial fractures.
  • Treated 20 ununited tibial fractures with autologous marrow injection over a five-year period.
  • Combined marrow injection with cast immobilization in 10 cases and intramedullary nail fixation in 10 cases.
  • Stimulated sufficient callus formation to unite 8 of 10 nonunions (80%) immobilized with casts.
  • Achieved union in 10 of 10 nonunions (100%) immobilized with intramedullary nails.
  • Provided outcomes comparable to historical open autologous grafting while reducing operative disadvantages.

Cite This Study

Connolly et al. (1991) studied this question.

synapsesocial.com/papers/6a716e2584cc45bb7bdff15ehttps://doi.org/10.1097/00003086-199105000-00038
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intramedullary Cylindrical Grafting for Nonunions of the Proximal Fifth Metatarsal2024
  2. 2NOVEL APPROACH: PERCUTANEOUS INJECTION OF BONE-SUBSTITUTE (CERAMENT-GTM) TO AID BONY HEALING IN STIFF NONUNITED COMPLEX OPEN TIBIAL FRACTURES2024
  3. 3Long bone uninfected non-union: grafting techniques2024 · 29 citations
  4. 4A case series utilizing bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma and autologous fibrin for the treatment of femur nonunions2024 · 3 citations
  5. 5Revision of Tibiotalar Arthrodesis Nonunion Using Intramedullary Fibular Autograft Combined with Cancellous Iliac Graft and Bone Marrow Aspirate Concentrate: A Case Report and Literature Narrative Review2026