Why the study?
Do secondarily generalized tonic-clonic seizures alter peri-ictal cardiac features compared to complex partial seizures in patients with medically refractory temporal lobe epilepsy?
Population
n=25 patients with medically refractory temporal lobe epilepsy undergoing presurgical investigation who had…
Comparison
Secondarily generalized tonic-clonic seizures vs Complex partial seizures
Design
Cohort
Authors
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Secondarily GTCS-associated autonomic changes and QTc shortening may heighten SUDEP risk; hypothesis-generating and requires prospective validation before guiding monitoring.
Do secondarily generalized tonic-clonic seizures alter peri-ictal cardiac features compared to complex partial seizures in patients with medically refractory temporal lobe epilepsy?
Secondarily generalized tonic-clonic seizures cause substantial autonomic disturbance and abnormal QTc shortening, which may contribute to sudden unexpected death in epilepsy (SUDEP).
Surges et al. (2010) studied this question.
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