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The aim is to investigate the molecular and structural changes in mitochondria of skeletal muscle induced by Zidovudine in rats.

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.

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The aim is to investigate the molecular and structural changes in mitochondria of skeletal muscle induced by Zidovudine in rats.
35 days of Zidovudine treatment in a rat model of toxic myopathy.
Assessment of molecular, biochemical, and ultrastructural alterations in skeletal muscle mitochondria.
Comparison of mitochondrial DNA and RNA levels, along with polypeptide synthesis between treated and control rats.
Significant mitochondrial swelling, disrupted cristae, and myelin figures observed in AZT-treated muscle.
Decreased levels of mtDNA and mtRNA noted, along with reduced mitochondrial polypeptide synthesis.
Mitochondrial DNA polymerase activity remained unchanged between AZT-treated and control groups.

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Randomized trial uncovers molecular and structural mitochondrial changes in rats, suggesting harmful effects of Zidovudine.

Lewis et al. (1992) studied this question.

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