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September 14, 1979Science

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

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Authors

ECEd CadmanCancer Research InstituteRHRobert HeimerYale UniversityLDLynn DavisResearch Triangle Park Foundation

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Cadman et al. (1979) studied this question.

synapsesocial.com/papers/6a716f98febe604dd70a1b48https://doi.org/10.1126/science.472732
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  1. 1Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.1978 · 195 citations
  2. 25-Fluoro-2′-Deoxyuridylate: Covalent Complex with Thymidylate Synthetase1972 · 170 citations
  3. 3EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT1965 · 42 citations