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July 1, 1972Proceedings of the National Academy of SciencesOpen Access

5-Fluoro-2′-Deoxyuridylate: Covalent Complex with Thymidylate Synthetase

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Authors

DSDaniel V. SantiNorthwestern UniversityCMCharles S. McHenryUniversity of Colorado Boulder

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Santi et al. (1972) studied this question.

synapsesocial.com/papers/6a704ed8a528af2d65c37335https://doi.org/10.1073/pnas.69.7.1855
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Enzymatic Synthesis of Thymidylate1962 · 222 citations
  2. 2Tetrahydrofolate-dependent Labilization of the Hydrogen Atom on Carbon 5 of 5'-Deoxycytidylate, a Step in the Deoxycytidylate Hydroxymethylase Reaction1967 · 42 citations
  3. 3Model studies of thymidylate synthetase. Neighboring-group facilitation of electrophilic substitution reactions of uracil furanosides1968 · 68 citations